منابع مشابه
Original CIN: reviewing roles for APC in chromosome instability
You may have seen the bumper sticker "Eve was framed." Thousands of years of being blamed for original sin and still many wonder, where's the evidence? Today, the tumor suppressor adenomatous polyposis coli (APC) may have the same complaint about accusations of a different type of CIN, chromosome instability. A series of recent papers, including three in this journal, propose that loss of APC f...
متن کاملRutherford Backscattering Spectrometry (RBS)
Rutherford Backscattering Spectrometry (RBS) is a widely used method for the surface layer analysis of solids. This lecture gives a brief introduction into the method, and describes scattering kinematics, scattering cross-section data, stopping power data, detector resolution issues, and electronic energy loss straggling in some detail. Computer codes for the simulation of RBS spectra and RBS d...
متن کاملThe wages of CIN
Aneuploidy and chromosome instability (CIN) are hallmarks of the majority of solid tumors, but the relationship between them is not well understood. In this issue, Thompson and Compton (Thompson, S.L., and D.A. Compton. 2008. Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell. Biol. 180:665-672) investigate the mechanism of CIN in cancer cells and find tha...
متن کاملPaola Dal Cin
Double minutes (dmin) and homogeneously staining regions (hsr) are the cytogenetic hallmarks of genomic amplification in cancer, more common in solid tumors than in hematologic malignancies. Double minute chromosomes are seen primarily in acute myeloid leukemia, with amplification of the MYC oncogene or, less frequently, the MLL transcription factor (Rayeroux and Campbell 2009). Both normal and...
متن کاملLEEP Verses Cryotherapy in CIN.
OBJECTIVE To compare the effectiveness and safety profile of LEEP (Loop Electrosurgical Excision Procedure) verses cryotherapy in the treatment of CIN. MATERIAL AND METHOD Women with abnormal pap smears were subjected to VIA and VILLI followed by colposcopy. A total of 200 cases were included in this prospective study. Once the diagnosis of CIN was confirmed on histopathology, the women were ...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2010
ISSN: 0890-9369
DOI: 10.1101/gad.1948010